I have installed VisualStudio 2010 for quite some time but suddenly it becomes very, very slow, and opening a project with dozens of files will take over 3-4 minutes, but it used to work very fast, on the same computer, the same os …
I suspect that there might be some conflict since I had installed 2012 version as well. But it turns out that this is not the cause of the poor performance.
After googling, I then find the solution here: delete all the folders named “Temporary ASP.net” on your computer.
There is a good tip to get where these folders are located. Use Everything search (free tools) and search with the keyword “Temporary ASP.net”, it will output all the folders on your PC instantly, as shown in the below snapshots. Delete all these folders, typically beneath Microsoft.Net\ folder.
Start VS and enjoy.
BTW: This also solved another problem for my VS: copy and cut is extremely slow, whereas paste is fine. After deleting these folders, all works fine!
Xinyustudio 
Not what I was thinking but wonderful anyway! Good for you!
Still after cleaning Temporary ASP.Net Very slow 😦 – VS takes > 4 min just to launch on an i7 with SSD and 8GB of ram. Spins and spins and spins. I will keep hunting for solutions…
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above solution does not resolved the issue but yes got a bit better. . . but after clearing the system with TFC = “Temp File Cleaner” (URL = http://addpcs.com/software/tfc/#/downloads) my VS now works quite good. . . thanks for the help.